Antigen-Specific T Cells to Carcinoembryonic Antigen (CEA) Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Human Monocytes for Immunology and Inflammation Research Monocyte is part of the innate immune response and functions to regulate cellular homeostasis, especially in the setting of infection and inflammation.[1] They account for approximately 5-10% of circulating nucleated cells in normal adult blood. Monocytes are the largest white blood cell, measuring between 12 to 20…
Recall Antigen Response as a Model for In Vitro T Cell Response In vitro T cell-based assay is an important tool for functional characterization of immunomodulatory drug candidates. For example, in the field of immune-oncology (I/O), interest is focused on efforts to better understand and manipulate the immune system to either overcome tolerance or promote…
Antigen-Specific T Cells to MUC1 Antigen Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Antigen-Specific T Cells Against NY-ESO-1 Antigen Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and challenging…
Expanded Natural Killer Cells As Research Tool | Ignyte Bio Natural killer (NK) cells are an important subset of lymphocytes for providing our body’s first line of defense. NK cells were originally described for their capacity to spontaneously kill tumor cells without prior sensitization which distinguishes them from cytotoxic T lymphocytes (CTLs). Mature…
MLR (Mixed Lymphocyte Reaction) As A Model for In Vitro T Cell Response In vitro T cell-based assay is an important tool for functional characterization of immunomodulatory drug candidates. For example, in the field of immune-oncology (I/O), interest is focused on efforts to better understand and manipulate the immune system to either overcome tolerance or…
Antigen-Specific T Cells for Melanoma Research: Tyrosinase Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Antigen-Specific T Cells for Melanoma Research: MART-1 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Irradiated PBMC as Research Tools Irradiated PBMC are PBMC from normal donors that have been subjected to high frequency ionizing X-Ray or gamma radiation. This exposure creates DNA damage that prevents certain cells (e.g., T cells, NK cells, B cells) from undergoing cell division. Irradiated PBMC components retain cellular functions, such as cytokine secretion, cytotoxicity,…
