Antigen-Specific T Cells Against NY-ESO-1 Antigen Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and challenging…
Expanded Natural Killer Cells As Research Tool | Ignyte Bio Natural killer (NK) cells are an important subset of lymphocytes for providing our body’s first line of defense. NK cells were originally described for their capacity to spontaneously kill tumor cells without prior sensitization which distinguishes them from cytotoxic T lymphocytes (CTLs). Mature…
MLR (Mixed Lymphocyte Reaction) As A Model for In Vitro T Cell Response In vitro T cell-based assay is an important tool for functional characterization of immunomodulatory drug candidates. For example, in the field of immune-oncology (I/O), interest is focused on efforts to better understand and manipulate the immune system to either overcome tolerance or…
Antigen-Specific T Cells for Melanoma Research: Tyrosinase Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Antigen-Specific T Cells for Melanoma Research: MART-1 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…
Irradiated PBMC as Research Tools Irradiated PBMC are PBMC from normal donors that have been subjected to high frequency ionizing X-Ray or gamma radiation. This exposure creates DNA damage that prevents certain cells (e.g., T cells, NK cells, B cells) from undergoing cell division. Irradiated PBMC components retain cellular functions, such as cytokine secretion, cytotoxicity,…
Donor-to-Donor Variation in Response to 3 Critical Recall Antigens Peripheral blood mononuclear cells (PBMC) are useful tools for evaluating immune response because they represent most of the resident immune cells in a donor’s sample, including T cells, B cells, natural killer (NK) cells, and monocytes. Varying Responses to Today’s Most Relevant Antigens In addition…
