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Fc gamma Receptor (FcgR) Gene Polymorphism (SNP) in Assay Development Knowledge of Fc gamma receptor (FcγR) gene polymorphisms (SNP) may be a useful tool for bioassay development in antibody-based studies.  Ignyte Bio offers FcγRIIa-131 and FcγRIIIa-158 genotype data from our donors without additional charge. Below is a short primer on FcγR SNP and its role…

Antigen-Specific T Cells to Prostate-Specific Membrane Antigen (PSMA) Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent…

Antigen-Specific T Cells to Human Cytomegalovirus (CMV) Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…

CD4+ T Cells Specific for NY-ESO-1 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells (both CD4+ and CD8+) to target some of today’s…

Target Cells for Assays with Antigen-Specific T Cells (ASpecT)   Antigen-specific T cells (ASpecTs) are a major player in the immune response in various diseases including cancer and pathogenic infections, as well as mediators in inflammation and autoimmunity.  Ignyte Bio offers assay-ready ASpecT products for your research with the following characteristics: Typically generated using multiple…

Antigen-Specific T Cells (ASpecT): A Tool for Immuno-Oncology (IO) Studies Our scientists were among the first to develop custom Antigen-Specific T cells (ASpecT) for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of ASpecT (both CD4+ and CD8+) to target…

Antigen-Specific T Cells to GAD65 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells (both CD4+ and CD8+) to target some of today’s most…

Antigen-Specific T Cells to Carcinoembryonic Antigen (CEA) Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…

Human Monocytes for Immunology and Inflammation Research   Monocyte is part of the innate immune response and functions to regulate cellular homeostasis, especially in the setting of infection and inflammation.[1] They account for approximately 5-10% of circulating nucleated cells in normal adult blood. Monocytes are the largest white blood cell, measuring between 12 to 20…

Recall Antigen Response as a Model for In Vitro T Cell Response In vitro T cell-based assay is an important tool for functional characterization of immunomodulatory drug candidates. For example, in the field of immune-oncology (I/O), interest is focused on efforts to better understand and manipulate the immune system to either overcome tolerance or promote…

Antigen-Specific T Cells to MUC1 Antigen   Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…

Antigen-Specific T Cells Against NY-ESO-1 Antigen Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and challenging…

Expanded Natural Killer Cells As Research Tool | Ignyte Bio   Natural killer (NK) cells are an important subset of lymphocytes for providing our body’s first line of defense. NK cells were originally described for their capacity to spontaneously kill tumor cells without prior sensitization which distinguishes them from cytotoxic T lymphocytes (CTLs).   Mature…

MLR (Mixed Lymphocyte Reaction) As A Model for In Vitro T Cell Response In vitro T cell-based assay is an important tool for functional characterization of immunomodulatory drug candidates. For example, in the field of immune-oncology (I/O), interest is focused on efforts to better understand and manipulate the immune system to either overcome tolerance or…

Antigen-Specific T Cells for Melanoma Research: Tyrosinase Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…

Antigen-Specific T Cells for Melanoma Research: MART-1 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…

Irradiated PBMC as Research Tools Irradiated PBMC are PBMC from normal donors that have been subjected to high frequency ionizing X-Ray or gamma radiation. This exposure creates DNA damage that prevents certain cells (e.g., T cells, NK cells, B cells) from undergoing cell division. Irradiated PBMC components retain cellular functions, such as cytokine secretion, cytotoxicity,…

Neutrophils for Allergies and Inflammation Research   Neutrophils are the most abundant leukocyte of peripheral blood and are known as the immune system’s first response to infection and injury. Recent studies have shown neutrophils’ effect in the regulation of both innate and adaptive immune response (A. Mocsai, 2013).  Exposure to allergen leads to recruitment of…

FAQs on Using Dendritic Cells for Immuno-oncology and Autoimmunity Research and Development Dendritic cells are a family of immune cells that help to maintain balance in the immune system. The dendritic cell family is typically divided into four subgroups: Conventional dendritic cells (DC1 and DC2) Plasmacytoid dendritic cells Inflammatory dendritic cells Langerhans cells Dendritic cells…

Anti-HPV E7 T Cells and the Fight Against Cervical Cancer Cervical cancer induced by human papillomavirus (HPV) remains a global concern with high mortality rates, especially for women in under-developed and under-served portions of the world. According to the CDC, over 47,000 HPV-associated cancers occur in the United States each year, with women representing about…

Antigen-Specific T Cells for Melanoma Researchers: gp100 Our scientists were among the first to develop custom antigen-specific T cells for research use and have created them against a diverse range of targets, including viral, tumor, and self-antigens. We’re now developing the next generation of antigen-specific T cells to target some of today’s most prevalent and…

The Increasing Relevance of Tregs in Immunology and Oncology The study of regulatory T cells in autoimmunity, oncology, and infectious disease is still very much in its early days, though the applicable research findings are piling up. Recent studies have linked the importance of Tregs to key areas of immunology:1 Autoimmune Disease: Tregs have been…

Donor-to-Donor Variation in Response to 3 Critical Recall Antigens Peripheral blood mononuclear cells (PBMC) are useful tools for evaluating immune response because they represent most of the resident immune cells in a donor’s sample, including T cells, B cells, natural killer (NK) cells, and monocytes.   Varying Responses to Today’s Most Relevant Antigens In addition…

The Value of Donor Data Transparency in Biomaterial Sourcing In the spirit of open sharing and collaboration between scientists, we make all our donor data available to you as you’re selecting the best human immune cell products for your research. After all, we’re scientists, not salespeople. That means you don’t have to fill out a…